Boehringer, OSE dose first cancer patient in SIRP antagonist trial

BI 765063 is a first-in-class checkpoint inhibitor that is licensed to and being developed under the partnership agreement between both companies Boehringer Ingelheim and OSE Immunotherapeutics recently confirmed that dosage of the first patient in the first-in-human Phase 1 clinical trial of BI 765063 is complete. The trial is reportedly designed to evaluate BI 765063, formally known as OSE-172, the first in-class monoclonal antibody antagonist that is currently being studied in patients who are suffering from advanced solid tumors. Apparently, the Phase 1 study includes dose finding study of B1 765063 (myeloid checkpoint inhibitor) that is administered as a single agent combined with monoclonal antibody PD-1 antagonist BI 754091, which is a T-lymphocyte checkpoint inhibitor. Jonathon Sedgwick, Senior Vice President and Global Head of Cancer Immunology & Immune Modulation Research at Boehringer Ingelheim, said that the company is pleased with the progress on B1 765063 while the product development has marked an important milestone by dosing the first patient. Boehringer Ingelheim is committed to the making new innovations in cancer immunology therapies with the aim to improve outcomes for patients with cancers that are difficult to treat. This commitment is exemplified due to the advancement of myeloid cell checkpoint that blocks monoclonal antibody into the clinic, Sedgwick mentioned.   Source Credit- https://www.boehringer-ingelheim.com/press-release/bi-765064-sirp-antibody-phase-i-started